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Particulate Interactions in Dry Powder Formulation for Inhalation
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Powder Production and Particle Engineering for Dry Powder
Particle Engineering for Improved Dispersion in Dry Powder Inhalers
Particulate interactions in dry powder formulations for
Particle Engineering for Improved Pulmonary Drug Delivery
Dry powder method development for laser diffraction particle
DEM Analysis of Particle Adhesion during Powder Mixing for
Aug 31, 2003 excipient–drug interactions are minimized in the case of the smooth-surfaced scf-crystallized particles leading to increased dispersion.
Dry powder rheology remains a grand challenge requiring integration and collaboration of theoretical, experimental and modeling programs. Further, it is recognized that multiple regimes of particle flow co-exist in many industrial processes, complicating the challenge to apply fundamental theories and/or models.
Jun 10, 2020 keywords: inhalation; pulmonary drug delivery; dry powder inhaler; of the a and b particles; those between the adhesive interactions were.
Dry powder inhalers consist of@a formulation, metering system and delivery device. The formulation consists of small drug particles (median aerodynamic.
Dry powders consisting of micro- or nano-sized particles are inherently adhesive and cohesive, leading to highly variable dose accuracy and poor aerosol.
Most previous studies of density of dry powder packings using dem simulations were focused on monodisperse systems and included either van der waals interactions 7,11,12 or adhesive forces during.
Particle interactions in dry powder inhaler unit processes: a review.
Efficient and reproducible dispersion and aerosolization of particles is critical to the optimal performance of dry powder inhaler (dpi) formulations for pulmonary.
The original method of dry granulation employed a heavy duty tablet press to compact the dry powder. The compacting process in this case is known as slugging and the compacted material was therefore in the form of “slugs” - typically 25 mm in diameter and 10-15 mm thick. A hammer mill is ideal for breaking up the slugs to create granules.
Dry powder inhalers are commonly formulated as interactive mixtures comprising micronised drug particles and large inert carrier particles. The properties of the carrier surface, particularly surface roughness, are believed to critically affect drug–carrier interactions and ultimately, determine the inhaler performance.
Particulate interactions in dry powder formulations for inhalation by xian ming zeng, gary p martin and christopher marriott.
Interactions between drug particulates are crucial in determining drug dispersion and deaggregation, and ultimately delivery efficiency. This book combines principles and factors in pharmaceutical powder technology, critically reviews some of the studies carried out in dry powder formulation development, and proposes possible strategies for improving their efficiency.
There is a regulatory expectation to determine foreign particulate matter (fpm) in respiratory drugs.
Particle interactions in complex dry powder inhaled formulations and single particle aerosol mass spectrometry. 2018, doctoral thesis, university of basel, faculty of science.
Particle interactions involved in aerosol dispersion of ternary interactive mixtures particle interactions involved in aerosol dispersion of ternary interactive mixtures louey, margaret; stewart, peter 2004-10-10 00:00:00 purpose. To investigate the mechanism of action of ternary components within dry powder aerosols.
Dry powder method development for laser diffraction particle size distribution measurements dry dispersion measurements are quicker than for liquid dispersion measurements, and also enable larger volumes of sample to be measured.
The interparticulate interfacial interactions that impact dpi aerosol dispersion are van der waals forces, electrostatic forces, and capillary forces.
Particle engineering, a core strength of lonza, is critical in achieving the particle size distribution required for effective drug delivery using dry powder inhaler.
Effect of mechanical dry particle coating on the improvement of powder flowability for lactose monohydrate: a model cohesive pharmaceutical powder powder technology, 2011 david morton.
In part at least this is due to an inadequate understanding of the relevant particle- particle interactions between drug and drug, and drug and carrier.
In order to reach the lower airways, the drug needs to have an aerodynamic particle size between 1 and 5 µm [10,11].
Recent development and methods of designing and optimizing dry powder formulations have extended the therapeutic potential of inhaled dosage forms. Successful drug delivery as indicated by a high and reproducible fine particle fraction, required to achieve the desired therapeutic effect while minimizing potential toxicity, depends on an understanding of the physico-chemical.
The delivery efficiency of dry-powder products for inhalation is dependent upon the drug formulation, the inhaler device, and the inhalation technique. Dry powder formulations are generally produced by mixing the micronised drug particles with larger carrier particles.
Particulate interactions in dry powder formulation for inhalation pharmaceutical science series: amazon.
Effect of particle interactions on powder flow behavior the study of powder flow behavior is essential for the development of processing technologies in many industries. In fact, powders have a major function in diverse types of manufacturing, such as pharmaceuticals, foods, chemicals, materials, minerals and cosmetics.
Failure to study some of the physical properties of the materials may be one of the most important causes of the lack of understanding of particle dispersal processes, the prediction of product performance, batch to batch variations and particle interactions, in dry powder inhaler (dpi) formulations.
• particle-particle interactions • dry particle coating – nano-additives • cohesion, flow and roles of nano-additives (valverde/castellanos) • cohesion/flow characterization using several powder testers (dave, sanchez-quintanilla, valverde, wassgren) • contact modeling – influence of nano-additives (yuhua chen and dave) • appendices.
Key words: dry powder inhaler; fluidization; particle re-suspension; powder flow; ternary interfacial interactions (14).
The in vitro aerosol performance of two combination dry powder inhaler (dpi) products, foster® nexthaler® and seretide® diskus® were investigated with single particle aerosol mass spectrometry (spams). The in-vitro pharmaceutical performance is markedly different for both inhalers.
T1 - the influence of relative humidity on particulate interactions in carrier-based dry powder inhaler formulations.
15087 dft metered dose inhaler (mdi) and dry powder inhaler (dpi) products - quality considerations guidance for industry draft guidance.
The use of the colloid afm technique in combination with the cohesive-adhesive balance (cab) approach provided a very accurate means of predicting dry powder formulation behaviour and the specific influence of particulate interactions on aerosol performance.
The influence of relative humidity on particulate interactions in carrier-based dry powder inhaler formulations.
Interactions between drug particulates are crucial in determining drug dispersion and deaggregation, and ultimately delivery efficiency. This book combines principles and factors in pharmaceutical powder technology, critically reviews some of the studies carried out in dry powder formulation development, and proposes possible strategies for improvi.
Dry powder inhaler (dpi) is a device used to deliver a drug in dry powder form to the lungs. A wide range of dpi products is currently available, with the choice of dpi device largely depending on the dose, dosing frequency and powder properties of formulations. Computational fluid dynamics (cfd), together with various particle motion modelling tools, such as discrete particle methods (dpm.
Dry pressing is an established process in the production of components from technical the interaction between the grains determines the complex powder.
The character of particulate systems is central to the performance of dpis. Dry powder inhalers versus metered-dose inhalers advantages of the dry powder inhaler environmental sustainability, propellant-free design little or no patient coordination required formulation stability.
Dry powder inhalers (dpis) are devices that deliver medications to the lungs to treat respiratory diseases such as asthma and chronic obstructive pulmonary.
Nov 7, 2014 cohesive and adhesive interactions of blended particles, and for predicting dry powder inhaler performance.
There are two main kinds of formulation for dry powder inhalers (dpi): the these formulations are based on the use of micron-sized particles containing the the interactions between the filling system and powder have to be understo.
Such conditions are obtained in inclined disks (pans), rotating drums, powder mixers, and fluidized beds. In pressure agglomeration, enlarged entities are formed by applying external forces to essentially dry particulate solids in more or less closed dies that define the shape of the agglomerated product.
This thesis focusses on the preparation of dry powder formulations and the investigation of the complex mechanisms that affect the dispersion during inhalation. Despite several years of research on particle-particle interactions that occur in carrier-based systems, there are still essential issues that remain unclear [9,10].
Abstract: understanding the adhesive interactions between active pharmaceutical ingredient (api) particles and carrier particles in dry powder inhalers (dpis) is critical for the development of formulations and process design. In the current study, a discrete element method (dem), which.
In the tribology community, there are primarily two types of dry particulate lubricants that are studied—granular and powder. Granular lubricants usually refer to dry, cohesionless, hard particles that transfer momentum and accommodate surface velocity differences through shearing and rolling at low shear rates, and collisions at high shear.
When electron cloud size is the same, then we will look at the surface area for molecular interaction to compare strength of id-id attraction.
Feb 1, 2019 keywords: dry powder inhaler (dpi), drug particle attributes, lung biology, carrier characteristics, particle interactions, clearance mechanism.
The performance of dry powder aerosols for pulmonary delivery is known to depend on fluidization and dispersion which reflects particle interactions in static.
Particulate interactions in dry powder formulation for inhalation (pharmaceutical science) by xian ming zeng (2000-10-26) on amazon.
Currently, the aerosol performance between dry powder inhalers varies to a large extent due to differences in the design of inhaler device and formulation. The particulate properties have a significant influence on the inter-particle interactions, which impacts on the aerosolisation of the inhaled powder.
Apr 30, 2015 the particle-particle interactions between particles in the sub-5 µm region steckel h, muller bw, “in vitro evaluation of dry powder inhalers.
Excipient interactions in glucagon dry powder inhaler formulation for pulmonary delivery md abdur rashid 1,*, amged awad elgied 1, yahya alhamhoom 1, enoch chan 2,5, llew rintoul 3, ayman allahham 4 and nazrul islam 2,5,* 1 department of pharmaceutics, school of pharmacy, king khalid university, abha,.
Particulate interactions in dry powder formulation for inhalation 1st edition by xian ming zeng; gary peter martin; christopher marriott and publisher crc press. Save up to 80% by choosing the etextbook option for isbn: 9781135729776, 1135729778. The print version of this textbook is isbn: 9780367397975, 0367397978.
Nov 23, 2016 dry powder inhalers are accepted as being complex drug products due to the interactions which occur between the active pharmaceutical and isolating the particles of interest within a dry powder inhaler (dpi) formulati.
Dry powders for inhalation, although clinically effective, tend to be inefficient in terms of the extent and reproducibility of drug delivery. In part at least this is due to an inadequate understanding of the relevant particle-particle interactions between drug and drug, and drug and carrier.
Particle interactions in complex dry powder inhaled formulations and single particle aerosol mass spectrometry inauguraldissertation zur erlangung der würde eines doktors der philosophie vorgelegt der philosophisch-naturwissenschaftlichen fakultät der universität basel von martin jetzer aus baden (ag), schweiz basel, 2019.
Parameters you want to measure for these investigations include particle size, pore size, particle structure, zeta potential, surface area, reactive area, density, powder flow, and many more.
Particle interactions play a significant role in controlling the performance of dry powder inhalers (dpis), which mainly arise through van der waals potentials,.
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